[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

Name	Licofelone
Synonyms	ML 3000 Licofelone Licofelone, ML-3000 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl- [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
CAS	156897-06-2
EINECS	694-581-3

Molecular Formula	C23H22ClNO2
Molar Mass	379.88
Density	1.23
Melting Point	162-163°C
Boling Point	539.7±50.0 °C(Predicted)
Solubility	Soluble in water (0.5 mg/ml at 25 °C), ethanol (~5 mg/ml), DMSO (20 mg/ml), DMF (20
Appearance	Pale yellow solid
Color	Off-White to Light Yellow
pKa	4.47±0.10(Predicted)
Storage Condition	-20°C Freezer
Use	An inhibitor of Cox-1, Cox-2, and 5-lipoxygenase.
In vitro study	The IC 50 s of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively.

Licofelone is a dual inhibitor of COX/LOX and is used to treat osteoarthritis.

Last Update：2022-10-16 17:41:28

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CAS: 156897-06-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid Request for Quotation